{"id":21439,"date":"2026-04-20T10:26:09","date_gmt":"2026-04-20T10:26:09","guid":{"rendered":"https:\/\/ideainthebox.com\/index.php\/2026\/04\/20\/red-wolves-colossal-biosciences-clones\/"},"modified":"2026-04-20T10:26:09","modified_gmt":"2026-04-20T10:26:09","slug":"red-wolves-colossal-biosciences-clones","status":"publish","type":"post","link":"https:\/\/ideainthebox.com\/index.php\/2026\/04\/20\/red-wolves-colossal-biosciences-clones\/","title":{"rendered":"Colossal Biosciences said it cloned red wolves. Is it for real?"},"content":{"rendered":"<div>\n<p>If you want to capture something wolflike, it\u2019s best to embark before dawn.<\/p>\n<p>So on a morning this January, with the eastern horizon still pink-hued, I drove with two young scientists into a blanket of fog. Forty miles to the west, the industrial sprawl of Houston spawned a golden glow. Tanner Broussard\u2019s old Toyota Tacoma bumped over the levee-top roads as killdeer, flushed from their rest, flew across the beams of his headlights.\u00a0<\/p>\n<p>Broussard peered into the darkness, looking for traps. \u201cI have one over here,\u201d he said, slowing slightly. A master\u2019s student at McNeese State University, he was quiet and contemplative, his bearded face half-hidden under a black ball cap. \u201cNothing on it,\u201d he said, blandly. The truck rolled on.<\/p>\n<p>Wolves and their relations\u2014dogs, jackals, coyotes, and so on\u2014are classed in the family <em>Canidae<\/em>, and the canid that dominated this landscape in eastern Texas was once the red wolf. But as soon as white settlers arrived on the continent, <em>Canis rufus <\/em>found itself under siege. The war on wolves \u201clasted 200 years,\u201d federal researchers once put it, in a surprisingly evocative report. \u201cThe wolf lost.\u201d By 1980, the red wolf was declared extinct in the wild, its population reduced to a small captive breeding population.<\/p>\n<p>Still, for decades afterward, people noted that strange wolflike creatures persisted along the Gulf Coast. Finally, in 2018, scientists confirmed that some local coyotes were more than coyotes: They were taller, long-legged, their coats shaded with hints of cinnamon. These animals contained relict red wolf genes. They became known as the ghost wolves.<\/p>\n<p>Broussard grew up in southwest Louisiana, watching coyotes trot across his parents\u2019 ranch. The thrilling fact that these might have been not just coyotes but something more? That reset a rambling academic career. In 2023, Broussard had recently returned to college after a seven-year pause, and his budding obsession with wolves narrowed his focus. Before he finished his bachelor\u2019s degree, he began to supply field data to a prominent conservation nonprofit.<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" fetchpriority=\"high\" decoding=\"async\" width=\"1920\" height=\"1282\" src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/2412_GW_2Month_2_1.jpg?w=1920\" data-orig-src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/2412_GW_2Month_2_1.jpg?w=1920\" alt=\"a wolf pup chews on a terrycloth toy\" class=\"lazyload wp-image-1135314\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271920%27%20height%3D%271282%27%20viewBox%3D%270%200%201920%201282%27%3E%3Crect%20width%3D%271920%27%20height%3D%271282%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/2412_GW_2Month_2_1.jpg 1920w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/2412_GW_2Month_2_1.jpg?resize=300,200 300w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/2412_GW_2Month_2_1.jpg?resize=768,513 768w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/2412_GW_2Month_2_1.jpg?resize=1536,1026 1536w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1920px) 100vw, 1920px\"><figcaption class=\"wp-element-caption\">The American red wolf, <em>Canis rufus,<\/em> is the most endangered wolf species in the world. This pup is one of four animals said to be clones of this native North American species.<\/figcaption><div class=\"image-credit\">COURTESY OF COLOSSAL BIOSCIENCES<\/div>\n<\/figure>\n<\/div>\n<p>Then, last year, just before he began his master\u2019s studies, he woke to disconcerting news. A startup called Colossal Biosciences claimed to have resuscitated the dire wolf, a large canid that went extinct more than 10,000 years ago. Pundits debated the utility of the project and whether the clones\u2014technically, gray wolves with some genetic tweaks\u2014could really be called dire wolves. But what mattered to Broussard was Colossal\u2019s simultaneous announcement that it had cloned four red wolves. \u00a0<\/p>\n<p>\u201cThat surprised pretty much everybody in the wolf community,\u201d Broussard said as we toured the wildlife refuge where he\u2019d set his traps. The Association of Zoos and Aquariums runs a program that sustains red wolves through captive breeding; its leadership had no idea a cloning project was underway. Nor did ecologist Joey Hinton, one of Broussard\u2019s advisors, who had trapped the canids Colossal used to source the DNA for its clones. Some of Hinton\u2019s former partners were collaborating with the company, but he didn\u2019t know that clones were on the table.<\/p>\n<p>There was already disagreement among scientists about the entire idea of de-extinction. Now Colossal had made these mystery clones, whose location was kept secret. Even the <em>purpose<\/em> of the clones was murky to some scientists; just how they might restore red wolf populations was unclear.\u00a0<\/p>\n<p>Red wolves had always been a contentious species, hard for scientists to pin down. The red wolf research community was already marked by the inevitable interpersonal tensions of a small and passionate group. Now Colossal\u2019s clones became one more lightning rod. Perhaps the most curious question, though, was whether the company had cloned red wolves at all.\u00a0<\/p>\n<hr class=\"wp-block-separator has-alpha-channel-opacity\">\n<p>You can think of the red wolf as the wolf of the East\u2014an apex predator that once roamed the forests and grasslands and marshes everywhere from Texas to Illinois to New York. Smaller than a gray wolf (though a good bit larger than a coyote), this was a sleek beast, with, according to one old field guide, a \u201ccunning fox-like appearance\u201d: long body, long legs; clearly built to run across long distances. Its coat was smooth and flat and came in many colors: a reddish tone that comes out in the right light, yes, but also, despite the name, white and gray and, in certain regions and populations, an ominous all black.<\/p>\n<p>We know these details thanks to a few notes from early naturalists. As writer Andrew Moore writes in his new book, <em><a href=\"https:\/\/www.harpercollins.com\/products\/the-beasts-of-the-east-andrew-moore?variant=43705534971938\">The Beasts of the East<\/a><\/em>, by the time a mammalogist decided to class these eastern wolves as a standalone species in the 1930s, the red wolf had been extirpated from the East Coast and was rapidly dwindling across its range. Working with remnant skulls and other specimens, the mammalogist chose the name red wolf\u2014which was later enshrined with the Latinate <em>Canis rufus\u2014<\/em>because that\u2019s what these wolves were called in the last place they survived.\u00a0<\/p>\n<p>The looming extinction of the red wolf turned out to be a good thing for coyotes. <em>Canis latrans <\/em>is a distant relative of wolves that split away from a common ancestor thousands of years ago and might be considered, as one canid biologist put it to me, the \u201cwolf of the Anthropocene.\u201d Their smaller size means they need less food and can survive in smaller and more fragmented territory, the kind that modern humans tend to build.\u00a0<\/p>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p style=\"font-size:30px\"><strong>The last red wolves, which lived in Louisiana and Texas, decided a strange and smaller mate was preferable to no mate at all.<\/strong><\/p>\n<\/blockquote>\n<p>Red wolves had kept coyotes out of eastern America, outcompeting them for prey. Now, as the wolves declined, the coyotes began to slip in. The last red wolves, which lived in Louisiana and Texas, decided a strange and smaller mate was preferable to no mate at all. Soon the territory became a genetic jumble, home to both wolves and coyotes and hybrids that, after several generations of intermixing, came in every shade between. Scientists call such a population a \u201chybrid swarm,\u201d and it poses a genetic threat to the declining species: As more coyotes poured east, and as all the canids kept interbreeding, there would be nothing that was \u201cpurely\u201d wolf.<strong>\u00a0<\/strong><\/p>\n<div class=\"wp-block-image\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" height=\"2000\" width=\"2667\" src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_094.jpg?w=2667\" data-orig-src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_094.jpg?w=2667\" alt='\"\"' class=\"lazyload wp-image-1135316\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272667%27%20height%3D%272000%27%20viewBox%3D%270%200%202667%202000%27%3E%3Crect%20width%3D%272667%27%20height%3D%272000%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_094.jpg 3000w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_094.jpg?resize=300,225 300w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_094.jpg?resize=768,576 768w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_094.jpg?resize=1536,1152 1536w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_094.jpg?resize=2048,1536 2048w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 2667px) 100vw, 2667px\"><figcaption class=\"wp-element-caption\">Ron Wooten surveys a location on the edge of Galveston Island State Park in Texas. In 2016, Wooten\u2019s photographs of oversized local coyotes got the attention of Joey Hinton, then a postdoctoral researcher at the University of Georgia.<\/figcaption><div class=\"image-credit\">TRISTAN SPINSKI<\/div>\n<\/figure>\n<\/div>\n<p>For years, no one seemed to notice. Perhaps trappers in the region mistook the new hybrids for wolves\u2014or were happy to take the higher bounty that a wolf pelt earned. Finally, though, by the 1960s, as the concept of endangered species first emerged, biologists began to worry for the disappearing wolf.\u00a0<\/p>\n<p>The best solution they could come up with was a program of mass extermination. Over several years, trappers rounded up hundreds of canids in Texas and Louisiana. Those deemed true red wolves (on the basis of their howls and skull shape) were whisked away to breed in captivity. Most of the rest were euthanized. In 1980, the red wolf was declared extinct in the wild. To put it plainly: The red wolf was wiped out intentionally, in a roundabout effort to keep it alive.<\/p>\n<p>Just 14 individuals survived this gauntlet; today\u2019s wolves descend from 12 of those. They became the ark, the source material for the few hundred red wolves that live today. There are about 280 in the \u201cSpecies Survival Plan\u201d population, living in captivity, and another 30 or so that roam a federal refuge in coastal North Carolina, and that the government deems \u201cnonessential\u201d and \u201cexperimental.\u201d According to the US Fish and Wildlife Service, to be classified as a representative of the protected entity known as <em>Canis rufus<\/em>, an animal must trace at least 87.5% of its lineage to the 12 founders.\u00a0<\/p>\n<p>The scientist who led this trapping-and-breeding program understood that the federal government would be narrowing the red wolf\u2019s gene pool precipitously\u2014so much so that the result could be an entirely new species. None of those notably black wolves persisted in the new population, for example. But what other choice existed? A new kind of wolf, free of the taint of the invading coyote, seemed better than no wolf at all.<\/p>\n<hr class=\"wp-block-separator has-alpha-channel-opacity\">\n<p>After I learned about Colossal\u2019s clones, I decided to travel to eastern Texas. The clones were hidden away on an unnamed refuge, but on this coastline, I might be able to at least see the animals that provided their genetic material. I arrived in the small town of Winnie on a balmy afternoon in January and met up with Broussard and another graduate student, Patrick Cunningham, at a Tex-Mex joint to discuss the challenges of studying red wolves.<\/p>\n<p>\u201cWe don\u2019t have a good reference genome,\u201d Cunningham said. We can collect DNA from the descendants of the 12 founders, but not from the countless wolves that had been killed. It\u2019s difficult to extract usable DNA from old samples. So our picture of what the species used to look like is limited.\u00a0<\/p>\n<p>Studies of the genes we do have, meanwhile, have proved controversial. When a Princeton geneticist named Bridgett vonHoldt dug into the genome of the Species Survival Plan population, she found little about their DNA that could set them apart from other wolflike American canids. In 2016, in a paper in <em>Science Advances<\/em>, vonHoldt and her coauthors wondered if there ever really <em>was<\/em> a separate southern wolf species. Perhaps the 12 founders were just coyotes injected with some smaller portion of wolf.<\/p>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p style=\"font-size:30px\"><strong>It\u2019s long been clear that North America\u2019s soup of <em>Canis<\/em> genes is something less like a family tree and more like a river\u2014one that\u2019s broken by islands and sandbars into many braided channels that split and merge and re-split.<\/strong><\/p>\n<\/blockquote>\n<p>Her paper called for complex new interpretations of the Endangered Species Act. We should, she wrote, focus less on <em>species<\/em> and more on the function a group of animals performs. The red wolves deserved protection, then, as creatures that filled the same role as truly endangered wolves and carried some of their genetics. Nonetheless, for <em>Canis rufus<\/em>, the timing of the paper was bad news.<\/p>\n<p>The red wolves roaming that federal reserve in North Carolina are supposed to be a first step toward the species\u2019 return to the wild. But some locals never liked the idea of living alongside wolves. By 2016, state officials had turned against the recovery program and were requesting its termination. The wild population, which had included as many as 120 a few years earlier, was falling. But the US Fish and Wildlife Service had paused further releases of wolves. Now a group of scientists, led by vonHoldt, was saying that the red wolf showed \u201ca lack of unique ancestry.\u201d Why spend money, some people wondered, on a species that does not exist?\u00a0<\/p>\n<p>Part of the problem was that the concept of a \u201cspecies\u201d is less sturdy than your high school biology teacher might have led you to believe. The most familiar definition is that a species consists of animals that can produce fertile offspring. But that\u2019s a rule various species of canids violate all the time; it\u2019s long been clear that North America\u2019s soup of <em>Canis<\/em> genes is something less like a family tree and more like a river\u2014one that\u2019s broken by islands and sandbars into many braided channels that split and merge and re-split.<\/p>\n<p>VonHoldt suggested that the modern red wolf is a channel in that river, part wolf and part coyote, that appeared surprisingly recently. But a year after her study came out, other researchers claimed that her data, if interpreted differently, could suggest that the red wolf braid had emerged tens of thousands of years ago, meaning this was a species that had long been on its own evolutionary journey.\u00a0<\/p>\n<p>These nuances were confusing for the policymakers who oversaw actual, living animals. \u201cCongress was just like, \u2018What is going on?\u2019\u201d Cunningham said. \u201c\u2018Why is there not just a simple explanation for what this thing is?\u2019\u201d<\/p>\n<p>Given the policy implications, the National Academies of Science, Engineering, and Medicine tasked a panel of scientists with finding that simple answer. Their report, published in 2019, declared that the red wolf <em>is<\/em>, by virtue of its appearance and seemingly long-standing isolated population, a species. As their study got underway, though, a new question was arising: What to make of the strange canids on the Gulf Coast, those today called the ghost wolves?<\/p>\n<hr class=\"wp-block-separator has-alpha-channel-opacity\">\n<p>The path to that name began in 2008, when a photographer from Galveston Island, Texas, grew obsessed with the oversized local coyotes. He began to take photos of the packs, which he distributed to scientists, seeking answers: What were they? By 2016, the photos had reached Joey Hinton, then a postdoctoral researcher at the University of Georgia.<\/p>\n<p>Hinton had spent more than a decade trapping wolves and coyotes in North Carolina, and his work has always focused on live animals, especially visual ways to distinguish red wolves and coyotes. So he was a good choice for helping the photographer, Ron Wooten, figure out the status of the canids. In his freezer Wooten also had tissue samples he\u2019d collected from road-killed coyotes. These could be used by a geneticist to give a fuller picture of the canids\u2019 ancestry. So vonHoldt was brought in too. The result was a 2018 paper, with Hinton as a coauthor, that identified the Galveston Island canids as at least part red wolf.<\/p>\n<p>These canids were not, to be clear, <em>actual<\/em> red wolves; no canid on the Gulf Coast is descended from the government\u2019s 12 canonical founders, so under current policy, none can be officially classified as a wolf. Subsequent studies have found that, on average, the ancestry of the region\u2019s canids is less than half red wolf, and often far less. In scientific terms, the red wolf had <em>introgressed<\/em> into the Gulf Coast population\u2014its genes had leaked across the species boundary and lodged themselves in a different population.<\/p>\n<p>Hinton, vonHoldt, and their coauthors also noted the presence of what they called \u201cghost alleles\u201d\u2014DNA sequences unknown in any other named species. The Occam\u2019s razor assumption was that, in these already wolfy coyotes, these sequences likely represented <em>Canis rufus<\/em> genetics that had not been captured in the sweep of the marsh that yielded the Species Survival Plan population. Since so much of the red wolf gene pool had been lost, these genes seemed to be a potential resource for the species\u2014a way to expand its diversity. When the <em>New York Times<\/em> covered this discovery a few years later, the headline popularized the \u201cghost wolf\u201d moniker that has proved so indelible.\u00a0<\/p>\n<p>As it happened, a separate team, focused on canids in and around federally protected marsh in Louisiana, published a similar paper in 2018, at nearly the same time. The twin discoveries raised new questions\u2014What should we make of these creatures, the latest branch in the canid river? What do they mean for the wolves in North Carolina?\u2014and helped researchers secure new funding.<\/p>\n<p>In 2020, vonHoldt and Kristin Brzeski, a former postdoc under vonHoldt and now a professor at Michigan Technological University, launched what they called the Gulf Coast Canine Project. Brzeski, who led the field work, hired Hinton to do much of the canid trapping and sample collection. In 2022, vonHoldt, Hinton, and Brzeski were all coauthors of another paper that identified even more red-wolf-descended canids in Louisiana and noted a positive correlation between red wolf ancestry and body mass\u2014the more red wolf genes, the bigger the animal. The paper also suggested that given this newly discovered reservoir of red wolf DNA, \u201cgenomic technologies\u201d could prove useful in the long-term survival of the species.<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" height=\"2000\" width=\"2389\" src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_140.jpg?w=2389\" data-orig-src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_140.jpg?w=2389\" alt='\"\"' class=\"lazyload wp-image-1135318\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272389%27%20height%3D%272000%27%20viewBox%3D%270%200%202389%202000%27%3E%3Crect%20width%3D%272389%27%20height%3D%272000%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_140.jpg 3000w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_140.jpg?resize=300,251 300w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_140.jpg?resize=768,643 768w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_140.jpg?resize=1536,1286 1536w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_140.jpg?resize=2048,1714 2048w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 2389px) 100vw, 2389px\"><figcaption class=\"wp-element-caption\">Bridgett vonHoldt (left) and Kristin Brzeski (center) visit a location where canids have been spotted with an animal control worker.<\/figcaption><div class=\"image-credit\">TRISTAN SPINSKI<\/div>\n<\/figure>\n<\/div>\n<p>VonHoldt and Brzeski eventually conceived of an ambitious project. They hoped that by carefully matching the most wolf-\u00addescended canids and breeding them together, over three generations they\u2019d increase the proportion of red wolf genes\u2014<em>de<\/em>-introgression. \u201cI\u2019m expecting, based on these pairings of animals, that I can stitch together the puzzle pieces,\u201d vonHoldt told me recently. \u201cWe are very likely to get puppies each generation that are higher and higher red wolf content\u201d\u2014enough wolf content, she hopes, to eventually win her permission to breed the resulting animals with the Species Survival Plan population of red wolves. They\u2019d essentially be adding a new founder to the limited lineage.<\/p>\n<p>Hinton told me he felt he\u2019d been kept in the dark about the de-introgression idea. He was also worried, he says, to learn that Colossal Biosciences hovered in the background. (In a draft proposal for the project, vonHoldt indicated that Colossal would be in charge of \u201clive capture.\u201d) Hinton says he was not comfortable collecting materials for a for-profit company that has to keep its shareholders happy.\u00a0<\/p>\n<p>Hinton says he reached out to state and federal officials and found they knew little about the project. (The US Fish and Wildlife Service declined to make anyone available for an interview for this story, and the Louisiana Department of Wildlife and Fisheries did not reply to requests for comment.) He knew the group\u2019s next phone call would be difficult, and indeed it was. He wound up speaking one-on-one with vonHoldt for at least half an hour.<\/p>\n<p>\u201cWe didn\u2019t reach an agreement,\u201d he says. After the call, he sent her a text: He was exiting the project. He believes that had Colossal not been involved, they\u2019d all still be working as a team. Both vonHoldt and Brzeski declined to comment on what felt to them like a matter of interpersonal relationships rather than a scientific dispute. \u201cThere were challenges over time, and the tone and manner of the interactions became increasingly difficult to navigate productively,\u201d Brzeski said in an email.\u00a0<\/p>\n<hr class=\"wp-block-separator has-alpha-channel-opacity\">\n<p>Colossal was cofounded in 2021 by George Church, an eminent Harvard geneticist who, thanks to investors, could finally embark on a long-discussed dream. He wanted to make de-extinction a reality\u2014using CRISPR gene-editing technology to, say, turn a modern elephant into something like the extinct woolly mammoth. The concept has drawn skepticism from the beginning\u2014at best it would only be possible to make <em>something like<\/em> a woolly mammoth. Was there any point to that? Some scientists note that genes alone do not teach an animal how to exist in the world; indeed, since social structures affect how genes are expressed, an animal without parents may not effectively fill its ecological niche.<\/p>\n<p>Less reproachable, though, was Colossal\u2019s interest in partnering with scientists who, like vonHoldt and Brzeski, focus on extant species that are endangered. This gave more heft to Colossal\u2019s gee-whiz de-extinction projects: They would, along the way, supply technology that could save our natural world.<\/p>\n<p>For red wolves, such technologies could offer a quick way to expand the limited gene pool. Through genetic engineering, Colossal could take clones of the Gulf Coast canids and tune up the wolf, tune down the coyote. It would be a high-tech shortcut past vonHoldt and Brzeski\u2019s careful breeding program. \u201cYou can do the same thing much more precisely, much more quickly, much more efficiently, in vitro,\u201d says Matt James, Colossal\u2019s chief animal officer and the executive director of the Colossal Foundation, the company\u2019s nonprofit arm. VonHoldt notes that the old-fashioned approach, with breeding, means she has to take a few individual canids out of the wild, into captivity\u2014never ideal but, in her view, a worthwhile price for progress. The advantage of cloning, which Colossal has managed to do with blood samples alone, is that the wild canid populations can be kept intact.\u00a0<\/p>\n<p>VonHoldt has always been an advocate for wolves. Indeed, when she hypothesized that the red wolf had hybrid origins, in 2016, she\u2019d framed it as an argument for protecting the gray wolf, which the federal government was considering removing from the Endangered Species List. (In short: If all wolves were one wolf, then it was undeniable that the species\u2019 range had contracted precipitously.) But she\u2019d grown frustrated with the federal government\u2019s efforts to restore the red wolf, which after half a century had seen few meaningful successes, she says.\u00a0<\/p>\n<p>VonHoldt joined Colossal\u2019s scientific advisory board in 2023. \u201cI love the bold, the shock and awe,\u201d she told me, explaining her decision. She saw the fact that Colossal sparked controversy as an asset, given the problems she sees in conservation: \u201cGet something out there. Start pushing buttons and start forcing these conversations,\u201d she says. The red wolf was akin to a terminal patient who was ready to accept any and all therapies, however experimental. Why <em>not<\/em> embrace biotech?\u00a0<\/p>\n<p>She also notes that the federal budget for endangered species conservation is incredibly limited. Rely only on that money and \u201cwe can kiss our world goodbye,\u201d she said in an e-mail. The $100\u00a0million raised by the Colossal Foundation is essential, then, she says. As for the samples the team had collected on the Gulf Coast, she says, limited freezer space is often devoted to animals that are officially categorized as threatened or endangered, which the Gulf Coast canids are not. Colossal could take the samples, and the team passed them along to the company.<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" loading=\"lazy\" decoding=\"async\" height=\"2000\" width=\"1500\" src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/03182026JoeyHinton_041_t.jpg?w=1500\" data-orig-src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/03182026JoeyHinton_041_t.jpg?w=1500\" alt=\"Dr. Joey Hinton\" class=\"lazyload wp-image-1135315\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271500%27%20height%3D%272000%27%20viewBox%3D%270%200%201500%202000%27%3E%3Crect%20width%3D%271500%27%20height%3D%272000%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/03182026JoeyHinton_041_t.jpg 2250w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/03182026JoeyHinton_041_t.jpg?resize=225,300 225w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/03182026JoeyHinton_041_t.jpg?resize=768,1024 768w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/03182026JoeyHinton_041_t.jpg?resize=1500,2000 1500w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/03182026JoeyHinton_041_t.jpg?resize=1152,1536 1152w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/03182026JoeyHinton_041_t.jpg?resize=1536,2048 1536w\" data-sizes=\"auto\" data-orig-sizes=\"auto, (max-width: 1500px) 100vw, 1500px\"><figcaption class=\"wp-element-caption\">Ecologist Joey Hinton trapped the canids that Colossal Biosciences used to source the DNA for its clones. He dismisses the clones as a way for the company to earn headlines and attract funding.<\/figcaption><div class=\"image-credit\">RICH SAAL<\/div>\n<\/figure>\n<\/div>\n<p>It was Hinton\u2014a source for a former story\u2014who first alerted me to Colossal\u2019s work on red wolves; he described vonHoldt and Brzeski\u2019s de-introgression project, which won federal funding in late 2024, as nefarious-sounding work to \u201cdisappear\u201d canids off the Gulf Coast. But he did not have all the details of the project, which had changed after he left the team. He suggested they\u2019d be \u201cjust throwing animals together,\u201d whereas vonHoldt described a careful program of observing the canids in the wild so she could determine which acted most wolflike, findings she\u2019d cross-\u00adreference with their genetic data.<\/p>\n<p>\u00a0Colossal did not wind up participating in the de-\u00adintrogression project. But the company <em>is<\/em> doing work on the red wolf that \u00advonHoldt views as complementary: Its scientists are assembling a \u201cpangenome\u201d of North American canids by studying samples pulled from museums, universities, zoos, and other institutions. This data set is expected to clarify both what genetic sequences are shared across the entire canid family and what snippets differ in certain populations. The hope is that this will provide a clearer picture of the red wolf in its early days, before the coyotes arrived and the gene pool narrowed. That might shift what Colossal\u2019s James calls the government\u2019s arbitrary definition of the red wolf, to encompass more of the species\u2019 full former diversity.\u00a0<\/p>\n<p>The pangenome, then, might allow vonHoldt\u2019s de-\u00adintrogressed canids, descended from the Gulf coast canids, to qualify as actual red wolves. Indeed, James suggested to me that more information about historic red wolves might force the government to take a new look at the Gulf Coast canids; some individuals might have high enough red wolf ancestry to be classified <em>as <\/em>red wolves. (\u201cThat has management implications that terrify state and federal government,\u201d he added.)<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" loading=\"lazy\" decoding=\"async\" height=\"2000\" width=\"2720\" src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_188.jpg?w=2720\" data-orig-src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_188.jpg?w=2720\" alt=\"hair in Zip-Loc bags on a metal tray\" class=\"lazyload wp-image-1135319\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272720%27%20height%3D%272000%27%20viewBox%3D%270%200%202720%202000%27%3E%3Crect%20width%3D%272720%27%20height%3D%272000%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_188.jpg 3000w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_188.jpg?resize=300,221 300w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_188.jpg?resize=768,565 768w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_188.jpg?resize=1536,1129 1536w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_188.jpg?resize=2048,1506 2048w\" data-sizes=\"auto\" data-orig-sizes=\"auto, (max-width: 2720px) 100vw, 2720px\"><figcaption class=\"wp-element-caption\">Blood and tissue samples collected by the Galveston Island Humane Society from canid roadkill will be shipped to Princeton University for DNA analysis.<\/figcaption><div class=\"image-credit\">TRISTAN SPINSKI<\/div>\n<\/figure>\n<\/div>\n<p>The purpose of vonHoldt\u2019s de-introgression project is to bring back certain lost red wolf genes\u2014to create a whole new wolf lineage. But she has also pushed against the idea of \u201cgenetic purity,\u201d which she thinks limits what we protect with conservation laws; she told me emphasizing it reminds her of the human history of eugenics and \u201cmakes every part of my soul hurt.\u201d She cares less about what species are out there, in the landscape, than what ecological function the animals play, and she sees coyotes and red wolves as closely related animals that may have a role to play in one another\u2019s future survival.<\/p>\n<hr class=\"wp-block-separator has-alpha-channel-opacity\">\n<p>As for Colossal\u2019s clones, even vonHoldt seems to describe them as something less than a conservation breakthrough. They are a \u201cproof of principle that we, collectively, as a scientific community, know how to do it,\u201d she told me. If an urgent need arises to clone red wolves, the groundwork has been laid.\u00a0<\/p>\n<p>Hinton, meanwhile, is one of several scientists I spoke with who were skeptical Colossal was doing good science, given that so much is conducted behind closed doors. He implied that the clones were nothing but an empty showpiece, a way to earn headlines and attract funders. \u201cThe work is anything but symbolic,\u201d James responded via e-mail. \u201cIt expands the genetic toolkit available for critically endangered species, demonstrates scalable approaches to biodiversity restoration, and contributes directly to preserving imperiled lineages.\u201d He noted that Colossal had intentionally decided to avoid the \u201csnail\u2019s pace\u201d of the peer review process and suggested that the skepticism from scientists may actually be a \u201cpanicked response to being outpaced.\u201d<\/p>\n<p>Until some evidence confirms that the Gulf Coast canids\u2014the source material for the clones\u2014are red wolves, they can\u2019t legally be classified as such for federal conservation purposes. Nonetheless, Colossal\u2019s press release claimed that the company had \u201cbirthed two litters of cloned red wolves, the most critically endangered wolf in the world.\u201d On the same day that press release dropped, Colossal\u2019s CEO and cofounder, Ben Lamm, appeared on <em>The<\/em> <em>Joe Rogan Experience <\/em>and claimed that he had offered to create hundreds of red wolves for the federal government to use in recovery\u2014for free! He was miffed when the government, under the Biden administration, replied that it wanted to spend several years and many millions of dollars to study the <em>potential<\/em> for cloning before it would take any action. (The company has gotten more traction with the Trump administration, Lamm said.)<\/p>\n<p>When I first spoke to James at Colossal, he said that he was \u201ccognizant\u201d of the concerns over the names and labels and that the company\u2019s own materials described the clones as \u201cred \u2018ghost\u2019 wolves.\u201d He suggested that if anyone assumed the clones were <em>actual<\/em> red wolves, that was because journalists had failed to grasp the nuances of the science. But this phrase appears so late in a long document that it was cut off in some versions. Later, over email, James indicated that further analysis had convinced him that what the company had created <em>were<\/em> red wolves, and that anyone who disagreed either could not grasp the science or is \u201cso ideologically opposed to Colossal\u2019s conservation revolution that they are willing to compromise their scientific integrity.\u201d<\/p>\n<p>VonHoldt has had her own issues with the company\u2019s communications; she told me it was \u201cstressful\u201d when Lamm described the clones as red wolves\u2014which, she notes, \u201cfederally, they\u2019re not.\u201d But she values the company\u2019s work, she says, and \u201cthe thing that I value the most is shaking things up.\u201d People are paying attention to red wolves. If it\u2019s hard to decide what to call the animals on the Gulf Coast\u2014where some heavily wolfy animals live alongside others that are more coyote\u2014that\u2019s just proof that our concept of a \u201cspecies\u201d does not capture the complex realities on the ground.\u00a0<\/p>\n<hr class=\"wp-block-separator has-alpha-channel-opacity\">\n<p>In 2025, the same year as Colossal\u2019s wolf announcement, Hinton launched the Texas-Louisiana Canid Project. He\u2019s working in partnership with Broussard, the master\u2019s student at McNeese, in slightly different territory from vonHoldt and Brzeski\u2014and focusing more on the animals\u2019 appearance and behavior than their genes. The Gulf Coast canids are stable and faring better than the North Carolina red wolves, and his hope is that if we learn why they\u2019ve been successful for so many years, we might be able to help the official red wolf population, which is only just limping along.\u00a0<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" loading=\"lazy\" decoding=\"async\" height=\"2000\" width=\"2951\" src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_109.jpg?w=2951\" data-orig-src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_109.jpg?w=2951\" alt=\"a wolf crosses a road outside of the city\" class=\"lazyload wp-image-1135317\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272951%27%20height%3D%272000%27%20viewBox%3D%270%200%202951%202000%27%3E%3Crect%20width%3D%272951%27%20height%3D%272000%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_109.jpg 3000w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_109.jpg?resize=300,203 300w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_109.jpg?resize=768,520 768w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_109.jpg?resize=1536,1041 1536w, https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/04\/SCI-REDWOLVES_Spinski_109.jpg?resize=2048,1388 2048w\" data-sizes=\"auto\" data-orig-sizes=\"auto, (max-width: 2951px) 100vw, 2951px\"><figcaption class=\"wp-element-caption\">Galveston locals hope that the presence of these remarkable creatures\u2014red wolves or not\u2014might rein in the rapid development of the island\u2019s last stands of green.<\/figcaption><div class=\"image-credit\">TRISTAN SPINSKI<\/div>\n<\/figure>\n<\/div>\n<p>I had planned to join Hinton in the field, but by the time I was able to visit, he\u2019d had to go home to his family. So I joined Broussard on his last days trapping in Texas that season. Before I\u2019d left for Winnie, I\u2019d told my friends I\u2019d be out chasing the last surviving red wolves. But there, on the Gulf Coast, I came to understand that this was just as much a story about <em>coyotes<\/em>.<\/p>\n<p>That\u2019s what Broussard and Cunningham both called the creatures. Hinton does too; he considers the animals to be a specific \u201cecotype\u201d of coyote, featuring an injection of wolf DNA that has helped them adapt to the local marshes.\u00a0<\/p>\n<p>At vonHoldt\u2019s behest, I drove an hour down the coast to Galveston Island, where she and Brzeski began working with the island\u2019s animal control department; when locals find a coyote, the animal is captured so its blood can be collected and a GPS collar fitted on its neck. A small group of locals who support the project have come to call themselves the \u201cghost wolf team.\u201d They hoped that the presence of these remarkable creatures might rein in the rapid development of the island\u2019s last stands of green. Still, the people I spoke to in Galveston conceded that the animals were, if special, nonetheless a form of coyote.\u00a0<\/p>\n<p>VonHoldt describes Galveston Island as a potential model for what conservation could look like in the future. Top-down recovery hasn\u2019t been working, but helping more places fall in love with their local animals might. And for that to happen, we need to stop obsessing over whether or not something is a \u201cpure\u201d wolf. What matters, she argues, is that an animal is doing what a larger predator does in an ecosystem. She embraces the \u201cghost wolf\u201d name because, more than \u201cGulf Coast canid,\u201d it makes clear that there\u2019s something special on the coast\u2014something worth protecting.\u00a0<\/p>\n<p>Her vision is enticing: Focus on function over purity. Let evolution proceed. Stop protecting the wolf of the past and consider the wolf of the future. Such rapid genetic exchange may be necessary to help predators adapt to a hotter, increasingly shattered world, she says.\u00a0<\/p>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p style=\"font-size:30px\"><strong>If we throw out the concept of \u201cendangered species,\u201d will we really protect \u201cendangered functions\u201d instead?<\/strong><\/p>\n<\/blockquote>\n<p>Then again, we already know what\u2019s adapted to the world we\u2019re building: coyotes. The argument against genetic purity can sound like giving up on wolves entirely, with the possible exception of whatever specimens we produce in cloning facilities. And there is the matter of politics: If we throw out the concept of \u201cendangered species,\u201d will we really protect \u201cendangered functions\u201d instead? Under an administration already rolling back environmental protections, the likeliest outcome may be protecting nothing at all.<\/p>\n<p>I tried in Galveston, too, to see the coyotes. Ron Wooten, the local resident who helped alert scientists to this population, dropped some pins on a map, pointing me toward several likely spots. That evening, after the sun set, I chose a quiet road that passed through marshes until it reached the island\u2019s eastern beach. It was mating season, Wooten had noted. The animals should be on the move, he said; look to the bushes. As I drove up and down the road, my headlights revealed only empty darkness. No coyote. No wolf. Fitting, perhaps\u2014isn\u2019t absence the essence of a ghost? But whether this was a good omen was less clear. As individuals, these animals do best by avoiding us humans. As a group, their survival\u2014like the survival of the red wolves\u2014depends on our knowing that they are here, and were here, and deciding that is reason enough to care.<\/p>\n<p>In Winnie the next morning, I went out one last time with Broussard, and we struck out again. With no coyotes in his traps and the new semester looming, he decided to take down his game cameras. Back at the hotel, I caught at least an image of what I\u2019d been chasing: In black and white, the animals were appropriately silver, spectral, dashing across the midnight fields. In one clip, a canid paused and howled. \u201cThat\u2019s super cool,\u201d Broussard said quietly, as an echoing, interweaving chorus responded from somewhere deeper in the marsh.\u00a0<\/p>\n<p><em><a href=\"https:\/\/www.boyceupholt.com\/\">Boyce Upholt <\/a>is a journalist based in New Orleans and founding editor of <\/em><a href=\"https:\/\/southlandsmag.com\/\">Southlands<\/a><em>, a magazine about Southern nature.\u00a0<\/em><\/p>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>If you want to capture something wolflike, it\u2019s best to  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[226],"tags":[],"class_list":["post-21439","post","type-post","status-publish","format-standard","hentry","category-technology"],"acf":[],"_links":{"self":[{"href":"https:\/\/ideainthebox.com\/index.php\/wp-json\/wp\/v2\/posts\/21439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ideainthebox.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ideainthebox.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ideainthebox.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ideainthebox.com\/index.php\/wp-json\/wp\/v2\/comments?post=21439"}],"version-history":[{"count":0,"href":"https:\/\/ideainthebox.com\/index.php\/wp-json\/wp\/v2\/posts\/21439\/revisions"}],"wp:attachment":[{"href":"https:\/\/ideainthebox.com\/index.php\/wp-json\/wp\/v2\/media?parent=21439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ideainthebox.com\/index.php\/wp-json\/wp\/v2\/categories?post=21439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ideainthebox.com\/index.php\/wp-json\/wp\/v2\/tags?post=21439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}